Astrocytes are among the most abundant cell types in the adult brain, where they play an important role in many functions. Although astrocytes play an important role in brain homeostasis, they provide vital metabolites to neurons and also buffer water, ions and glutamate outside the cell. Astrocytes, one of the three parts of the synapse, are an integral part. However, it plays an important role in the formation, cleaning and maintenance of synapses. To accomplish these important events, astrocytes communicate with each other and with other glial cells, neurons, cerebral vasculature, and the extracellular environment through numerous specialized membrane proteins, including cell adhesion molecules, aquaporins, ion channels, neurotransmitter transporters, and cavity. Astrocytes, like neurons, rely on intracellular transport to be well-co-ordinated tightly and regularly to support dynamic flow.